PDRN Serums and Skincare

A PDRN serum is built around PDRN, short for polydeoxyribonucleotide, a name for mixtures of DNA fragments. Korean brands use it in serums, ampoules, creams, toners and sheet masks that aim for a more hydrated, smoother and visibly firmer look. Some formulas use salmon-derived PDRN, others vegan or plant-based PDRN, and on the ingredient list it can appear as Sodium DNA.

This collection gathers PDRN products from VT Cosmetics, Medicube, Centellian24, Mediheal and Mary&May. For a first try, pick one PDRN serum or ampoule and use it after cleansing and toning, then follow with moisturizer and, in the morning, sunscreen. Add one new product at a time so you can tell how your skin responds.

These are leave-on cosmetics, not clinic treatments. Read what PDRN in skincare is and how to read the label before you choose.